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KMID : 0376219710080010055
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Chonnam Medical Journal
1971 Volume.8 No. 1 p.55 ~ p.64
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Mechanism of Hemolysis by Hematin
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Abstract
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In the previous report it has´, been shown that oxytocin elicits diuresis ip rabbits by improving the hemodynamic state in the kidney. There is, however, a report that oxytocin exerts, its natriuretic effect by acting upon some intracranial structures in the dog (Chan et al), and there are experimental evidences indicating that structares located within the central nervous system are capable of altering the levels of urinary sodium. Henceforth, possible participation of some CNS structures in the diuretic action of oxytocin was explored in this study.
Oxytocin, introduced into the lateral ventricle of the rabbit brain in a dose of I0 mU/kg dissolved in 0.2 ml of 0.9% saline, produced decrements in urine flow, clearances of PAH and inulin and in the amounts of sodium excreted, whereas the same volume of saline had no influence upon the renal function. Increasing the dose to l00 mU/kg elicited greater responses. Significant correlations were ascertained between changes in renal plasma flow(RPF = CPAH) and glomerular filtration rate(GFR=C1?), between decreases in RPF and urine flow, as well as between changes in GFR and urine flow, suggesting that the primary action rests on the decrease in renal perfusion.
Phentolamine, a potent alpha adrenergic blocking agent, produced with a dose (1-2 mg/kg, I. v,) profound curtailments in urine flow, RPF, GFR and sodium excretion as a result of lowered systemic blood pressure. The antidiuretic effect of intracranial oxytocin was completely abolished after the pretreatment of animals with phentolamine, suggesting that the participation of sympatho- adrenal system in the renal response to intraventricular oxytocin.
These observations provide an evidence that in the diuretic action´ of intravenous Oxytocin, CNS plays no significant role.
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